• Air (oxygen)

    Oxygen in the atmosphere can cause oxidation of the drug contained in the capsule. On the one hand, during the filling and fitting process, a small amount of oxygen in the atmosphere will remain in the interior of the capsule along with the air, so that some of the medicine is oxidized. On the other hand, during the storage of the capsule, since the part is not completely sealed, the air will enter and exit the capsule as the temperature changes, so that the internal oxygen is continuously increased, making the medicine further oxidized. Therefore, when filling the easily oxidizable drug, the air should be removed as much as possible, and the capsule should be sealed storage after the filling is completed to improve the stability of the drug.

drug capsules

  • Humidity and moisture

    After the solid drug absorbs moisture, a liquid film is formed on the surface. Some drugs accelerate hydrolysis and oxidation under the influence of trace amounts of water. Excessive moisture can also cause the capsule to deform. Therefore, when filling and storing highly absorbent and unstable drugs, care should be taken to avoid contact with moisture. For example, the capsule drug cannot be stored in a damp place in the bathroom or kitchen.
  • Packaging materials

    The choice of packaging material has an impact on the stability of the finished capsule after filling. If the capsule is stored directly in a room temperature environment, it will be affected by heat, light, moisture, air, and the like. Therefore, a properly sealed package design can greatly reduce drug instability and ensure the quality of volatile drugs.