Enteric capsules can release the drug in the small intestine and large intestine through drug delivery technology, so that the drug can exert local or systemic therapeutic effects in the human intestinal tract.
It can be divided into intestinal enteric capsules (ie common enteric-coated capsules); colon-soluble enteric capsules.
Due to some special properties of the drug and medical needs, such as some drugs and gastric acid metamorphism, it has a strong stimulating effect on the gastric mucosa. Some drugs must act and absorb in the intestines, so enteric capsules are required.
Intestinal enteric capsule advantages:
1. Avoid the stimulation of the stomach after oral administration of the drug, thus reducing the side effects of some drugs on the stomach.
2. Prevent the degradation of drugs that are unstable to acid or gastric enzymes in the stomach, thereby improving the efficacy of the drug.
3. Control the release site of the drug so that the drug can be effectively absorbed in the small intestine.
Advantages of colon-soluble enteric capsules:
1. Avoid absorption of the drug in the stomach and small intestine, and reduce a series of side effects caused by the absorption of the drug into the stomach and small intestine.
2. Improve the local concentration of the drug in the large intestine, thus allowing the drug to fully exert its local therapeutic effect.
3. Reduce gastrointestinal irritation of certain drugs or side effects on the upper digestive tract.
4. Avoid the degradation of certain drugs in the stomach and small intestine, which can make oral application of protein or peptide drugs.
In addition, the colon-soluble enteric capsule is convenient to take the capsule compared with the enema administration. The drug is more widely distributed and more uniform in the colon.