Pharmaceutical preparations are inseparable from pharmaceutical excipients. The improvement of the quality of pharmaceutical preparations and the emergence of new dosage forms are often based on the development of new excipients. As one of the most widely used pharmaceutical excipients, HPMC can be used as an adhesive, a disintegrant, a sustained release agent, a coating film former, etc. due to its molecular weight and viscosity.
- As an adhesive and a disintegrant, HPMC can be used to promote drug dissolution and release.
The low viscosity HPMC dissolves in water to form a clear, creamy, viscous colloidal solution that acts directly as an adhesive. In addition, HPMC aqueous solution, mixed with a certain concentration of ethanol, or different concentrations of starch slurry can be made into different composite adhesives.
- HPMC is used to increase the compressibility of drug particles and promote drug disintegration.
- HPMC is used as a water-soluble coating material.
This solution has a moderate viscosity and good film formation and can maintain the shape of the sheet. In addition, the coating film also has the effects of coloring, moisture resistance and the like.
- HPMC is applied to mucoadhesives.
The mucoadhesive agent enables the drug to adhere to the mucosal epithelial site by means of the special adhesion of certain polymeric materials, thereby prolonging the residence and release time of the drug at the adherent site to reach the targeted administration time.