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As the main raw material, gelatin is easy to cause microbial contamination in the production process. In order to prevent microbial contamination problems, oxidizing substances such as hydrogen peroxide are added to the production process.
The self-propelled tiny capsules remove the outer shell and transport the drug directly to the tumor cells. The role of these micro-robots was confirmed in the mouse intestines. Perhaps one day, they will become targeted treatments for cancer and reach some hard-to-reach areas of the body. Related results were published in Science-Robotics.
The molecular weight ranges from 10,000 to 1,500,000. Hypromellose is divided into four subtypes depending on the content of methoxy and hydroxypropoxy groups, namely, 1828, 2208, 2906, and 2910. Calculating the dried product, the content of each substituted methoxy (-OCH3) and hydroxypropoxy (-OCH2CHOHCH3) should be in accordance with the following table.
Bubbles are one of the defects that may occur in the production process of gelatin capsules, because it not only affects the appearance of medicines or health care products, but may also break the capsule filling process, resulting in leakage of contents.
Standard of Pullulan for capsules -Tuesday, August 20, 2019
The product is a neutral polysaccharide produced in the process of culturing Aureobasidium pullulans. 3 glucose through α-1,4 glycosidic bonds to form maltotriose, and then repeated bonding through α-1,6 glycosidic bonds to make the structure of the pullulan.
Capsule drugs are used frequently in life. However, in actual production, the problem of softening of the capsule is often encountered, which is usually happened in spring and summer. The main reason is that the gel cap is not properly stored, which is affected by the temperature or adsorbs moisture in the air.
Empty enteric gelatin capsule standard -Sunday, August 18, 2019
This standard specifies the specifications, technical indicators and requirements, test methods, inspection rules, criterion rule and requirements of product packaging, labeling, transportation and storage of empty enteric gelatin capsules.This standard is applicable to empty hard capsules made of gelatin and auxiliary materials and suitable enteric coating materials, divided into enteric-coated capsules and colonic enteric-coated capsules, gelatin and enteric materials should meet medicinal requirements.
Empty HPMC capsule standard -Sunday, August 18, 2019
This standard specifies the specifications, technical indicators and requirements, test methods, inspection rules, criterion rule and requirements of product packaging, labeling, transportation and storage of empty HPMC capsules.This standard is applicable to empty HPMC hard capsules made of HPMC and auxiliary materials and HPMC should meet relevant requirements.
Conventional capsules are generally divided into two broad categories, hard capsules (for powder filling) and soft capsules (for filling oily oils, vitamins and other oily liquids). The liquid-filled hard capsule adopts a two-section structure and is made of gelatin or HPMC as a material for filling a liquid medicine.
Empty pullulan capsule standard -Friday, August 16, 2019
This standard specifies the specifications, technical indicators and requirements, test methods, inspection rules, criterion rule and requirements of product packaging, labeling, transportation and storage of empty pullulan capsules.This standard is applicable to empty pullulan hard capsules made of pullulan and auxiliary materials and pullulan should meet relevant requirements.