The loading volume of capsule pills or health care products will vary depending on factors such as the volume of the capsules and the filling process. A slight difference in the amount of loading does not have a significant effect, but if the difference in the amount of the load is too large, it will affect the efficacy of the capsule drug and the actual content of the component in the health care product. Therefore, it is necessary to minimize this difference in loading.
Empty capsule size
Before making a capsule drug or a health supplement, firstly determine the size of the capsule. The size selection needs to be determined according to the dose of the drug, the specific gravity of the powder, and the like. If the size of the empty capsules loaded with the powder is inconsistent, it is easy to cause a difference in the volume of the capsules.
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Powder factors may include powder uniformity, fluidity, and the like. The size of the powder particles has an effect on the filling of the capsule. Powder particles of different sizes are prone to density differences. Powder quantity can be different when powder with poor fluidity flowing into the metering disc hole (for the automatic capsule filling machine) during the filling process of the capsule.
In general, automatic capsule filling has less impact on the difference in the loading of capsules than manual filling. When manually operated, the operator's strength, operational proficiency, and fillings quantity will vary from time to time, resulting in uneven material distribution. In addition, after long-term use of the manual capsule filling machine, deformation, capsular hole wear may occur, resulting in a mismatch with the capsule, so as to different filling amounts.