Science and Technology Daily News According to a medical paper published by the British journal Nature Communications, Korean scientists have discovered the mechanism behind chemotherapy-induced permanent hair loss. The researchers transplanted human hair follicles into mice and identified changes in hair follicle stem cells caused by chemotherapy -- a change that can cause permanent hair loss.
Chemotherapy is one of the most effective means of treating cancer at present, and it is also called the three major treatments for cancer together with surgery and radiotherapy. Chemotherapy is actually the abbreviation of chemical drug treatment, that is, the use of chemical drugs to kill cancer cells for therapeutic purposes. But one side effect of chemotherapy is that some drugs may cause hair loss. In theory, this hair loss should be reversible. As a world-renowned capsule manufacturer, we are also very concerned about this matter.
Like many adult stem cells, hair follicles maintain a pool of regenerative cells that are damaged by chemotherapy. After hair loss due to chemotherapy, hair follicle stem cells can eventually recover and re-grow hair. However, it has been found that some chemotherapy causes loss of stem cell pool and causes permanent hair loss.
A research team at the Seoul National University School of Medicine in Korea transplanted human hair follicles into hairless mice to establish a chemotherapy-induced permanent hair loss model. Afterwards, the mice received a two-step chemotherapy regimen associated with permanent hair loss in humans. The researchers found that the first treatment caused cell proliferation, and the second treatment caused massive cell death, and the resulting stem cell depletion prevented hair regeneration. They provide evidence that cells are more sensitive to DNA damage when proliferating, which causes cell division problems that ultimately lead to cell death.